HCID 59558623, compound → HCID 59558324, compound

HRID 1175159Notes

Reaction equation

HRID 1175159 reaction equation
COC([CH:5]1[C:12](=[O:13])[C:9]2([CH2:11][CH2:10]2)[C:8]2([CH2:15][CH2:14]2)[NH:7][C:6]1=[O:16])=O>C(#N)C.O>[CH2:11]1[C:9]2([C:12](=[O:13])[CH2:5][C:6](=[O:16])[NH:7][C:8]32[CH2:14][CH2:15]3)[CH2:10]1

Participants

3

Reactant 1

HCID 59558623HCID 59558623, compound

Product 1

HCID 59558324HCID 59558324, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

8,10-Dioxo-7-aza-dispiro[2.0.2.4]decane-9-carboxylic acid methyl ester (628 mg; 2.2 mmol) in acetonitrile/water (9 ml/0.9 ml) is refluxed for 50 minutes, cooled to room temperature, filtered and the filtrate evaporated to deliver the title compound as colorless solid (386 mg; 98%).

Workup

  1. filtrationfiltered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-823225a050384db58be9f1a86cf54bc2
Source dataset
uspto-grants-2010_11
Patent number
US07838674B2

Reaction notes

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