HCID 59558606, compound → HCID 59558320, compound

HRID 1175161Notes

Reaction equation

HRID 1175161 reaction equation
COC([CH:5]1[C:12](=[O:13])[NH:11][C:8]2([CH2:10][CH2:9]2)[C:7]2([CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14]2)[C:6]1=[O:24])=O>C(#N)C.O>[C:20]([O:19][C:17]([N:15]1[CH2:16][C:7]2([C:6](=[O:24])[CH2:5][C:12](=[O:13])[NH:11][C:8]32[CH2:10][CH2:9]3)[CH2:14]1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 1

HCID 59558606HCID 59558606, compound

Product 1

HCID 59558320HCID 59558320, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

8,10-Dioxo-6,11-diaza-dispiro[2.0.3.4]undecane-6,9-dicarboxylic acid 6-tert-butyl ester 9-methyl ester (160 mg; 0.47 mmol) in acetonitrile/water (3 ml/0.3 ml) is refluxed for 1 hour and evaporated to dryness to deliver the title compound as off-white crystals (125 mg; 94%).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-e162dfb6ff8041e0950dd14ec07e0738
Source dataset
uspto-grants-2010_11
Patent number
US07838674B2

Reaction notes

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