反应详情

温度

35 °C

2-Chloro-6,7-dihydro-5H-quinazolin-8-one (570 mg; 3.1 mmol) is dissolved in HClconc (20 ml) and combined at room temperature with Br2 (500 mg; 3.1 mmol) in HClconc (3.4 ml). The reaction mixture is warmed to 35° C. for 10 minutes, poured on water and extracted with ethyl acetate three times. The combined organic phases are dried over Na2SO4, filtered and evaporated to dryness to deliver the title compound as brown-yellow crystals (740 mg; 91%) which are used in the next step without further purification.

1. additionpoured on water
2. extractionextracted with ethyl acetate three times
3. dry with materialThe combined organic phases are dried over Na2SO4
4. filtrationfiltered
5. customevaporated to dryness
6. customare used in the next step without further purification