HCID 57654652, compound → HCID 59558468, compound

Participants

Reaction Steps

{1-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-hydroxy-methyl]-cyclobutyl}-carbamic acid tert-butyl ester (1.2 g, 3.5 mmol) is refluxed in ethyl acetate for 4 hours. The solvent is removed in vacuo and the resulting residue is crystallized from ether. 1H-NMR (400 MHz; DMSO-d6): 12.5 (s, 1H), 4.73 (s, 1H), 2.87 (dt, 2H), 2.35-2.25 (m, 2H), 1.85 (quint, 2H), 1.51 (s, 9H); LC-MS (m/z, ES−): 238 (M−H), Retention time: 2.24 mins (LC-MS method 3)

Provenance & Evidence