Bromine → HCID 59558628, compound

Participants

Reaction Steps

2-(3-Chloro-4-morpholin-4-yl-phenyl)-6,7-dihydro-5H-quinazolin-8-one (328 mg, 0.95 mmol) is dissolved in acetic acid (7 ml) and HBrconc. (7 ml). Bromine in HBrconc. (0.95 ml 1N solution) is added at room temperature. After stirring for one hour the mixture is poured onto ice, neutralized with NaHCO3 and the product is extracted with ethyl acetate. 1H-NMR (400 MHz; DMSO-d6): 9.10 (s, 1H), 8.43 (s, 1H), 8.28 (d, 1H), 7.30 (d, 1H), 5.21(dd, 1H), 3.76 (brs, 4H), 3.09 (brs, 4H), 3.00-2.40 (m, 4H); LC-MS (m/z, ES+): 422 (MH+), Retention time: 3.05 mins (LC-MS method 2)

Provenance & Evidence