Sodium Hydroxide → HCID 68703308, compound

Participants

Reaction Steps

0.111 g (0.47 mmol) of the methyl ester of 2-amino-1,3a,5,7a-tetrahydroimidazo[4,5-b]pyridine-4-carboxylic acid 4 is added to 4 ml of a NaOH solution (1 ml). The reaction mixture is brought to reflux with stirring for 5 minutes (reaction monitored by TLC). After cooling, a phosphate buffer solution (pH=7) (20 ml) is added and the mixture is extracted with BuOH until exhausted. The organic phases are combined and evaporated to dryness to give 0.079 g of allyl amine 16 in the form of a brown solid with a yield of 85%.

Provenance & Evidence