HCID 86613782, compound → HCID 68690034, compound

Participants

Reaction Steps

To a solution of 3-(1-acetylpiperidin-2-yl)-5-(1-cyclohexylethyl)benzoate (80 mg, 0.22 mmol) in THF:MeOH:water (1:1:1, 6 mL) was added NaOH (6 N, 10 drops) and the mixture was stirred for 3 h. The volatiles were removed in vacuo and the mixture was acidified with aqueous HCl (6 N) to a pH of about 2. The mixture was extracted with EtOAc (3×10 mL). The combined organics were washed with water (1×10 mL), brine (1×10 mL), dried over sodium sulfate, filtered and concentrated. The title compound was used without further purification.

Provenance & Evidence