HuagongsheHuagongshe Chemistry Print Report · For research reference only
Veratrylamine → N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Veratrylamine | HCID 79832 | — |
| Reactant | 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21976427 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine | HCID 21976416 | 88.4% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A solution of 2-chloro-7-(2-fluorobenzyl)4(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine (254 mg, 0.78 mmol) in N-methylpyrrolidone (2 mL) was treated with veratrylamine (0.25 mL, 1.66 mmol), heated to 100° C. for 16 h and purified by chromatography (Heptane:EtOAc, 4:1) to give the title compound (316 mg, 88%) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098333B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-24ae2260c3ff44c886402ed1bd64b0dd |
| Source note | uspto-grants-2006_08 |