N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide → 2-Amino-4-methyl-1,3-thiazole-5-sulfonamide

Participants

Reaction Steps

A suspension of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]acetamide (the product from Example 53, step ii) (0.44 g) in hydrazine hydrate (1.5 ml) was stirred at room temperature for 4 h. The mixture was diluted with H2O and extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4), filtered and evaporated to give the subtitle compound as an off-white solid. Yield 0.23 g.

Provenance & Evidence