Trifluoroacetic acid → HCID 59558804, Verbindung

HRID 1175489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1175489
[Cl:1][C:2]1[C:3]([F:35])=[C:4]([CH:32]=[CH:33][CH:34]=1)[CH2:5][S:6][C:7]1[N:12]=[C:11]([NH:13][S:14]([N:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH:10]=[C:9]([O:30][CH3:31])[N:8]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([F:35])=[C:4]([CH:32]=[CH:33][CH:34]=1)[CH2:5][S:6][C:7]1[N:12]=[C:11]([NH:13][S:14]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)(=[O:15])=[O:16])[CH:10]=[C:9]([O:30][CH3:31])[N:8]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 53628397HCID 53628397, Verbindung

Produkt 1

HCID 59558804HCID 59558804, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The title compound was prepared according to the procedure outlined in example 15 using tert-butyl 4-[({2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidin-4-yl}amino)sulfonyl]piperazine-1-carboxylate (the product from step ii) (0.26 g), trifluoroacetic acid (0.5 mL) and DCM (10 mL). Purification was by reverse phase HPLC (Symmetry as the stationary phase and TFA/acetonitrile as the mobile phase) then triturated with MeOH followed by Et2O to give the title compound as a white solid. Yield: 40 mg

Aufarbeitung

  1. customThe title compound was prepared
  2. customPurification
  3. customthen triturated with MeOH

Quellen und Nachweise

ORD-Eintrag
ord-c66a274cc4fe4ea6875df6348c459a79
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07838675B2

Notizen zur Reaktion

Wird geladen…