4-Methyl-3-thiopheneboronic acid → N-Isobutyl-2-methyl-2-(4-(4-methylthiophen-3-yl)phenyl)propanamide

HRID 1175566Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1175566
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=1.[CH3:18][C:19]1[C:20](B(O)O)=[CH:21][S:22][CH:23]=1>>[CH2:12]([NH:11][C:9](=[O:10])[C:8]([CH3:17])([C:5]1[CH:6]=[CH:7][C:2]([C:20]2[C:19]([CH3:18])=[CH:23][S:22][CH:21]=2)=[CH:3][CH:4]=1)[CH3:16])[CH:13]([CH3:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 50839314-Methyl-3-thiopheneboronic acidHCID 687750752-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide

Produkt 1

HCID 57331076N-Isobutyl-2-methyl-2-(4-(4-methylthiophen-3-yl)phenyl)propanamideAusbeute 67 %

Versuchsvorschrift

Prepared in a similar manner to Example 1 from 2-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide (Example 1a) and 4-methylthiophen-3-ylboronic acid. Yield: 67%. 1H NMR (400 MHz, dDMSO): δ 0.73-0.79 (d, 6H), 1.48 (s, 6H), 1.67-1.74 (m, 1H), 2.23 (s, 3H), 2.84-2.87 (m, 2H), 7.26-7.27 (m, 1H), 7.34-7.40 (m, 5H), 7.43-7.44 (d, 1H). MS(M+H, 316).

Quellen und Nachweise

ORD-Eintrag
ord-2eff0402b5244574b1f2c8f093c6bc9d
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842324B2

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