Flurbiprofen → HCID 58789390, compound

Participants

Reaction Steps

Prepared in a similar manner to Example 3 from 2-(2-fluorobiphenyl-4-yl)propanoic acid and furan-2-ylmethanamine. Yield: 75%. 1H NMR (500 MHz, CDCl3): δ 1.55-1.56 (d, 3H), 3.56-3.58 (m, 1H), 4.35-4.40 (dd, 1H, J1=5.3 Hz, J2=15.5 Hz), 4.45-4.49 (dd, 1H, J1=5.7 Hz, J2=15.6 Hz), 5.72 (s br, 1H), 6.16 (d, 1H, J=2.7 Hz), 6.39 (m, 1H), 7.10-7.15 (m, 2H), 7.25-7.45 (m, 5H), 7.54 (m, 2H).

Provenance & Evidence