Thiophene-3-boronic acid → N-isobutyl-2-methyl-2-(4-(thiophen-3-yl)phenyl)propanamide
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=1.[S:18]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19]1>>[CH2:12]([NH:11][C:9](=[O:10])[C:8]([CH3:17])([C:5]1[CH:6]=[CH:7][C:2]([C:20]2[CH:21]=[CH:22][S:18][CH:19]=2)=[CH:3][CH:4]=1)[CH3:16])[CH:13]([CH3:15])[CH3:14]Participants
3
Procedure
Prepared in a similar manner to Example 1 from 2-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide (Example 1a) and thiophen-3-ylboronic acid. MS (M+H, 302).
Sources & evidence
- ORD record
- ord-53e4fd9fab94411f9e0414bb99665895
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842324B2
Reaction notes
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