(3-hydroxyphenyl)boronic Acid → 2-(3'-hydroxybiphenyl-4-yl)-N-isobutyl-2-methylpropanamide

HRID 1175574Notes

Reaction equation

HRID 1175574 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=1.[OH:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1>>[OH:18][C:19]1[CH:24]=[C:23]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=2)[CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 2734359(3-hydroxyphenyl)boronic AcidHCID 687750752-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide

Product 1

HCID 587893532-(3'-hydroxybiphenyl-4-yl)-N-isobutyl-2-methylpropanamideYield 70%

Procedure

Prepared in a similar manner to example 8 from 2-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide (Example 1a) and 3-hydroxyphenylboronic acid. Yield: 70%. MS (M+H, 312).

Sources & evidence

ORD record
ord-898bb1fd09554a5d8c81d0611bb58df9
Source dataset
uspto-grants-2010_11
Patent number
US07842324B2

Reaction notes

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