1,2-Dimethylpropylamine, (R)- → (R)-N-sec-butyl-2-(4-(5-cyanopyridin-3-yl)phenyl)-2-methylpropanamide

Participants

Reaction Steps

Prepared in a similar manner to Example 3 from 2-(4-(5-cyanopyridin-3-yl)phenyl)-2-methylpropanoic acid (example 21a) and (R)-3-Methyl-2-butylamine. Yield 48%. 1H NMR (400 MHz, DMSO): δ 0.71-0.73 (d, 3H), 0.74-0.76(d, 3H), 0.91-0.93 (d, 3H), 1.46 (s, 3H), 1.47 (s, 3H), 1.59 (m, 1H), 3.58 (m, 1H), 6.98-7.01 (d, 1H), 7.42-7.44 (d, 2H), 7.77-7.79 (d, 2H), 8.64 (s, 1H), 8.98 (s, 1H), 9.17 (s, 1H). MS (M+H, 336).

Provenance & Evidence