2-Methylbutylamine → 2-methyl-N-(2-methylbutyl)-2-(4-(pyrimidin-5-yl)phenyl)propanamide

Participants

Reaction Steps

Prepared in a similar manner to Example 20 from 2-methyl-2-(4-(pyrimidin-5-yl)phenyl)propanoic acid (example 25a) and 2-methylbutan-1-amine. Yield: 58%. 1H NMR (400 MHz, dMSO): δ 0.72-0.74 (d, 3H), 0.79-0.84 (m, 3H) 0.97-1.00 (m, 1H), 1.24-1.27 (m, 1H), 1.47 (m, 1H), 1.48 (s, 6H), 2.81-2.87 (m, 1H), 2.93-2.98 (m, 1H), 7.37-7.39 (t, 1H), 7.44-7.47 (d, 2H), 7.76-7.79 (d, 2H), 9.13 (s, 1H), 9.18 (s, 1H); MS+H (312.1).

Provenance & Evidence