Isobutylamine → 2-(4-(5-(ethoxymethyl)pyridin-3-yl)phenyl)-N-isobutyl-2-methylpropanamide

Participants

Reaction Steps

Prepared in a similar manner to Example 3 from 2-(4-(5-(ethoxymethyl)pyridin-3-yl)phenyl)-2-methylpropanoic acid (example 26a) and isobutylamine. Yield: 80%. 1H NMR (400 MHz, dMSO): δ 0.72 (s, 3H); 0.74 (s, 3H); 1.15 (t, 3H, J=6.8); 1.46 (s, 6H); 1.68 (m, 1H); 2.83 (t, 2H, J=5.6); 3.51 (q, 2H, J=7.2); 4.54 (s, 2H); 7.4 (t, 1H); 7.41 (d, 2H, J=6.4); 7.66 (d, 2H, J=6.8); 7.95 (t, 1H, J=2.4); 8.49 (d, 1H, J=1.6); 8.78 (d, 1H, J=2.8). MS (M+H, 355).

Provenance & Evidence