3-Bromo-5-(ethoxymethyl)pyridine → 2-(4-(5-(Ethoxymethyl)pyridin-3-yl)phenyl)-2-methylpropanoic acid

HRID 1175593Notes

Reaction equation

HRID 1175593 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][O:9][CH2:10][CH3:11])[CH:7]=1.B([C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])=[CH:17][CH:16]=1)(O)O>>[CH2:10]([O:9][CH2:8][C:6]1[CH:7]=[C:2]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])=[CH:17][CH:16]=2)[CH:3]=[N:4][CH:5]=1)[CH3:11]

Participants

3

Reactant 2

HCID 219843463-Bromo-5-(ethoxymethyl)pyridineHCID 509991372-(4-Boronophenyl)-2-methylpropanoic acid

Product 1

HCID 687762972-(4-(5-(Ethoxymethyl)pyridin-3-yl)phenyl)-2-methylpropanoic acidYield 90%

Procedure

Prepared in a similar manner as example 21a starting from 3-Bromo-5-(ethoxymethyl)pyridine (example 26b) and 2-(4-boronophenyl)-2-methylpropanoic acid (example 21b). Yield: 90%. MS (M+H, 300).

Workup

  1. customPrepared in a similar manner as example 21a

Sources & evidence

ORD record
ord-82749e67acec4145bc1bc32aa3a5abdf
Source dataset
uspto-grants-2010_11
Patent number
US07842324B2

Reaction notes

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