Sodium Hydroxide → HCID 68775456, compound

Participants

Reaction Steps

Ethyl 2-(2-methoxy-5′-(methoxymethyl)biphenyl-4-yl)-2-methylpropanoate (example 27b) (986 mg, 2.88 mmol) was suspended in EtOH (10 mL) and 1M aq. NaOH (15 mL) and stirred at 100° C. for 3 h. EtOH was removed under reduced pressure and the residue was diluted with water (10 mL) and acidified with 6N aq. HCl to pH 2-3. The product was extracted with EtOAc, washed with water and brine, dried over MgSO4, filtered and evaporated to give 900 mg (99%) of 2-(2-Methoxy-5′-(methoxymethyl)biphenyl-4-yl)-2-methylpropanoic acid. 1H NMR(400 MHz, DMSO): δ 1.48 (s, 6H), 3.29 (s, 3H), 4.45 (s, 2H), 7.40-7.61 (m, 8H), 12.44 (s, 1H).

Provenance & Evidence