HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-thiopheneboronic acid → Ethyl 2-(3-methoxy-4-(4-methylthiophen-3-yl)phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-thiopheneboronic acid | HCID 5083931 | — |
| Reactant | Ethyl (3-methoxy-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate | HCID 58820079 | — |
| Product | Ethyl 2-(3-methoxy-4-(4-methylthiophen-3-yl)phenyl)acetate | HCID 68775428 | 72% |
Reaction Steps
Prepared in a similar manner to example 1 from ethyl 2-(3-methoxy-4-(trifluoromethylsulfonyloxy)phenyl)acetate (example 27d) and 4-methylthiophen-3-ylboronic acid. Yield: 72%. 1H NMR (400 MHz, dMSO): δ 1.19-1.22 (m, 3H), 2.00 (s, 3H), 3.62 (s, 2H), 3.69-3.73 (m, 3H), 4.08-4.13 (m, 2H), 6.86-6.88 (d, 1H), 6.98-6.99 (d, 1H), 7.08-7.10 (d, 1H), 7.16-7.17 (t, 1H), 7.26-7.27 (d,1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842324B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-ad391cb7dfed4f9ebfbd57e4f9441513 |
| Source note | uspto-grants-2010_11 |