5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile → HCID 68774417, compound

Participants

Reaction Steps

Prepared in a similar manner to Example 23 from 2-(6-bromopyridin-3-yl)-N-isobutyl-2-methylpropanamide (example 40a) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile. Yield: 47%. 1H NMR (400 MHz, dMSO): δ 0.72-0.74 (d, 6H), 1.51 (s, 6H), 1.66-1.69 (m, 1H), 2.82-2.86 (m, 2H), 7.62-7.64 (m, 1H), 7.82-7.85 (m, 1H), 8.10-8.12 (d, 1H), 8.65-8.66 (d, 1H), 8.89-8.90 (t,1H), 9.05-9.06 (d, 1H), 9.50-9.51 (d, 1H); MS+H (323).

Provenance & Evidence