Boron tribromide → HCID 53403683, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(5-bromopyridin-2-yl)-2-methylpropanoate (514 mg, 2 mmol) was dissolved in dry DCM (10 mL) and cooled to −10° C. BBr3 (20 mL of 1M solution in DCM) was added drop-wise under argon to the solution. The reaction mixture was stirred 30 min at −10° C. and then at room temperature for 72 h and evaporated to give 2-(5-Bromopyridin-2-yl)-2-methylpropanoic acid used in the next step without further purification. MS+H (244, 246).

Provenance & Evidence