2-Methoxypropan-1-amine → 2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(2-methoxypropyl)-2-methylpropanamide

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxypropan-1-amine	HCID 12609719	—
Reactant	2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid	HCID 68776443	—
Product	2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(2-methoxypropyl)-2-methylpropanamide	HCID 16005272	70%

Reaction Steps

Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and 2-methoxypropan-1-amine. Yield 70%. 1H NMR (400 MHz, dMSO): δ 0.93-0.94 (d, 3H), 1.48-1.49 (d, 6H), 2.99-3.11 (m, 2H), 3.17 (s, 3H), 3.29-3.30 (m, 1H), 7.41-7.42 (m, 1H), 7.49-7.51 (d, 2H), 8.11-8.14 (d, 2H), 9.15 (s, 1H), 9.55 (s, 1H); MS+H (339).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07842324B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-1c2b2b01fa734838892d4dbc7561a57d
Source note	uspto-grants-2010_11