(R)-sec-butylamine → (R)-N-sec-butyl-2-(4-(6-cyanopyrazin-2-yl)phenyl)-2-methylpropanamide

HRID 1175635Notes

Reaction equation

HRID 1175635 reaction equation
[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([CH3:20])([CH3:19])[C:16]([OH:18])=O)=[CH:11][CH:10]=2)[CH:6]=[N:5][CH:4]=1)#[N:2].[CH3:21][C@@H:22]([NH2:25])[CH2:23][CH3:24]>>[C@H:22]([NH:25][C:16](=[O:18])[C:15]([C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:6]=[N:5][CH:4]=[C:3]([C:1]#[N:2])[N:8]=2)=[CH:14][CH:13]=1)([CH3:20])[CH3:19])([CH2:23][CH3:24])[CH3:21]

Participants

3

Reactant 2

HCID 2724537(R)-sec-butylamineHCID 687764432-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid

Product 1

HCID 16005273(R)-N-sec-butyl-2-(4-(6-cyanopyrazin-2-yl)phenyl)-2-methylpropanamideYield 43%

Procedure

Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and (R)-butan-2-amine. Yield 43%.

Sources & evidence

ORD record
ord-e77ac9e845994dc785bae36886421637
Source dataset
uspto-grants-2010_11
Patent number
US07842324B2

Reaction notes

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