HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Methyl-2-furanmethanamine → 2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(1-(furan-2-yl)ethyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Methyl-2-furanmethanamine | HCID 90729 | — |
| Reactant | 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid | HCID 68776443 | — |
| Product | 2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(1-(furan-2-yl)ethyl)-2-methylpropanamide | HCID 68778790 | 35% |
Reaction Steps
Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and 1-(furan-2-yl)ethanamine. Yield 35%. 1H NMR (400 MHz, dMSO): δ 1.32-1.33 (d, 3H), 1.49-1.52 (d, 6H), 5.09 (m, 1H), 6.06 (d, 1H), 6.33-6.35 (dd, 1H), 7.49-7.51 (d, 2H), 7.54 (d, 1H), 8.12-8.14 (d, 2H), 9.16 (s, 1H), 9.56 (s, 1H); MS+H (361).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842324B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-88576478de17492ba199eef8a93f8dbf |
| Source note | uspto-grants-2010_11 |