HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pentanamine → 2-methyl-N-(pentan-3-yl)-2-(4-(pyrimidin-5-yl)phenyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pentanamine | HCID 12019 | — |
| Reactant | 2-Methyl-2-(4-(pyrimidin-5-yl)phenyl)propanoic acid | HCID 68777249 | — |
| Product | 2-methyl-N-(pentan-3-yl)-2-(4-(pyrimidin-5-yl)phenyl)propanamide | HCID 58789322 | 67% |
Reaction Steps
Prepared in a similar manner to Example 20 starting from 2-methyl-2-(4-(pyrimidin-5-yl)phenyl)propanoic acid (example 25a) and pentan-3-amine. Yield: 67%. 1H NMR (400 MHz, dMSO): δ 0.71-0.75 (m, 6H), 1.26-1.42 (m, 4H), 1.49 (s, 6H), 3.57-3.59 (m, 1H), 6.91-6.93 (d, 1H), 7.45-7.48 (d, 2H), 7.77-7.79 (d, 2H), 9.14 (s, 2H), 9.17 (s, 1H); MS+H (312).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842324B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-ae5c48a0dfee4ae08fa5002be7bf2aea |
| Source note | uspto-grants-2010_11 |