Triethylamine → HCID 11449786, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[4-(hydroxymethyl)phenoxy]phthalonitrile (1.0 g, 3.9 mmol) prepared according to procedures described in literature, and triethylamine (0.80 ml, 5.8 mmol) in anhydrous CH2Cl2 (50 ml), kept at 0° C. under stirring and in an inert atmosphere, methylsulfonylchloride was added (0.33 ml, 4.3 mmol). The mixture was stirred at 0° C. for 1 hour, then ft was diluted with CH2Cl2 (50 ml) and washed with 1% HCl solution (60 ml), then with brine (50 ml), the organic layer was dried on Na2SO4 and the solvent was evaporated. 1.2 g (92%) of the title compound were obtained as a viscous fluid that crystallised on standing.

Provenance & Evidence