Tetrabutylammonium Fluoride → HCID 25006396, compound

Participants

Reaction Steps

To a solution of compound 30.4 (288 mg, 0.46 mmol) in THF (20 mL) was added a 1N solution of tetrabutylammonium fluoride in THF (2.7 mL, 2.8 mmol). The mixture was stirred at r.t. for 1 h and concentrated down under reduced pressure. The residue was subjected to a silica gel column chromatography eluting with 10% MeOH in CH2Cl2 to give compound 30.5 (114 mg, 63% yield). 1H NMR (300 MHz, CD3OD): δ 1.38 (t, 6H, J=7.0), 1.40 (s, 3H), 3.86 (m, 2H), 4.02 (d, 1H, J=4.9), 4.11 (m, 4H), 4.56 (dd, 1H, J=7.0, 6.7), 5.98 (d, 1H, J=7.4), 6.11 (d, 1H, J=7.0), 7.63 (d, 1H, J=7.6). LRMS (ESI) MH+ C14H24N3O8P requires 394.4. Found 394.1.

Provenance & Evidence