Ethanol → 1',3'-Dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-indanone (67.8 mmol, 9 g) and ammonium carbonate (684 mmol, 66 g) in ethanol (150 ml) and water (150 ml) was added NaCN (201.9 mmol, 9.9 g) and the reaction mixture was stirred at 70° C. for 3 h. The reaction mixture was cooled to 0° C. and the precipitated product was filtered, washed with water (4×) and desiccated. LC/MS (10% to 99%): M/Z (M+H)+ (obs)=203; tR=1.78.

Provenance & Evidence