1-Methylisoquinoline → 1-methyl-5-nitroIsoquinoline

Participants

Reaction Steps

To a solution of 1-methyl isoquinoline (Aldrich) in concentrated sulfuric acid at 0° C. was added potassium nitrate (1.1 mmol). Reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. Reaction mixture was basified. Solid precipitated was column purified.

Provenance & Evidence