Sulfuric Acid → 4-Acetamido-6-chloro-3,4-dihydro-spiro[2H-1-benzopyran-2,1'-cyclobutane]

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Reaction Steps

A solution of 6-Chloro-3,4-dihydro-4-hydroxy-spiro[2H-1-benzopyran-2,1′-cyclobutane] (10 mmol) in acetonitrile (30-50 ml) was added to a solution of concentrated sulfuric acid (30 mmol) in acetonitrile (10 ml), at 0 to −10° C. The reaction mixture was stirred for about 2 hrs and was allowed to warm up, to room temperature. It was then added on ice. The corresponding acetamido derivative was separated out as a white solid which was filtered, washed with water and dried.

Provenance & Evidence