Ethanol → HCID 68698807, compound

HRID 1175787Notes

Reaction equation

HRID 1175787 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:10]([OH:12])[CH3:11].[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][C:14]1=O.[OH-].[Na+]>O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[C:11]1[C:17]2[C:16](=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:15](=[CH:14][C:13]2[CH:8]=[CH:7][CH:6]=[CH:3][C:2]=2[F:1])[C:10]1=[O:12]

Participants

6

Reactant 4

HCID 702Ethanol2×HCID 119832-IndanoneHCID 14798Sodium HydroxideHCID 67970o-Fluorobenzaldehyde

Product 1

HCID 68698807HCID 68698807, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1.88 g (15.13 mmol) of 2-fluorobenzaldehyde in 3.0 mL of abs. ethanol was added over a period of 5 min to a solution containing 1.00 g (7.57 mmol) of 2-indanone and 90 mg (2.27 mmol) of NaOH in 40 mL of a 1:1 mixture of abs.ethanol and water at room temperature. The mixture was allowed to stir for 12 hrs and solids formed were collected by suction filtration and washed with cold ethanol and dried under high vacuum.

Workup

  1. additionin 40 mL of a 1:1 mixture of abs
  2. customat room temperature
  3. customsolids formed
  4. filtrationwere collected by suction filtration
  5. washwashed with cold ethanol
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-fa8bb9d30e804ec4bd9237aa18c69299
Source dataset
uspto-grants-2010_11
Patent number
US07842705B2

Reaction notes

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