Ethanol → HCID 23153827, compound

Participants

Reaction Steps

A mixture of 4-chloro-1-benzyl-2-oxo-1,2-dihydroquinoline-3-carbonitrile (0.6 g), 4-(2-hydroxyethyl)phenylhydrazine (0.24 g), triethylamine (0.27 ml) and ethanol (40 ml) was heated under reflux for 12 hours. The solvent was distilled off under reduced pressure, and an aqueous sodium hydrogen carbonate solution was added thereto and extracted with ethyl acetate. The extract was washed with water and brine, dried and concentrated. The residue was purified with silica gel column chromatography to obtain the target compound (0.47 g).

Provenance & Evidence