反应详情

A solution of N,N-dimethyl4-(2-furyl)-7-(2-trimethylsilylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine (370 mg, 0.97 mmol) in THF (3 mL) was treated with tetrabutylammonium fluoride (1 ml, 1-M in THF, 1 mmol), refluxed for 36 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (EtOAc:Heptane, 1:9, alumina) to give the title compound (47 mg, 21%) as a yellow solid.

1. temperaturerefluxed for 36 h
2. extractionextracted with EtOAc
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. custompurified by chromatography (EtOAc:Heptane, 1:9, alumina)