Trifluoroacetic acid → HCID 135599892, compound

Participants

Reaction Steps

A mixture of 3-amino-5-(4-methoxybenzyl)-2-(2-methoxyphenyl)-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (370 mg), anisole (2 ml), trifluoroacetic acid (5 ml) and trifluoromethanesulfonic acid (1 ml) was stirred at room temperature for 3.5 hours. The mixture was concentrated under reduced pressure. To the mixture was added 5% sodium carbonate to adjust pH to about 9. Ethyl acetate was added to the mixture. An insoluble solid was collected by filtration, washed with water and ethyl acetate, and dried to obtain the target compound (250 mg).

Provenance & Evidence