Citric Acid → HCID 135997574, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-2-(4-methoxyphenyl)-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (150 mg), DL-methionine (371 mg) and methanesulfonic acid (3 ml) was stirred at 100° C. for 3 hours. The reaction mixture was cooled, pH of the reaction mixture was adjusted to about 8 by adding an aqueous 20% sodium hydroxide solution and a 10% aqueous citric acid solution. The precipitated solid was collected by filtration, washed with water and then dried to obtain the target compound (132 mg).

Provenance & Evidence