Ethanesulfonylchloride, 2-chloro- → HCID 135599964, compound

Participants

Reaction Steps

A mixture of 3,7-diamino-2-phenyl-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (150 mg), 2-chloroethanesulfonyl chloride (61.8 μl), diisopropylethylamine (108 μl) and tetrahydrofuran (5 ml) was stirred at room temperature for 30 minutes, 1-methylpiperazine (571 μl) and N,N-dimethylformamide (1 ml) were added thereto, and stirred at room temperature for one night. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified with aminopropylated silica gel column chromatography to obtain the target compound (25 mg).

Provenance & Evidence