Potassium Iodide → HCID 135599942, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-2-(3-methoxyphenyl)-7-hydroxy-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (150 mg), 4-(2-chloroethyl)morpholine hydrochloride (109 mg), potassium carbonate (163 mg), potassium iodide (5 mg) and N,N-dimethylformamide (5 mg) was stirred at 80° C. for 3 hours. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified with silica gel column chromatography. To the concentrated residue of fraction was added ethyl acetate. The precipitated solid was collected by filtration, washed with ethyl acetate, and dried to obtain the target compound (73 mg).

Provenance & Evidence