Trifluoroacetic acid → HCID 135599923, compound

Participants

Reaction Steps

A mixture of N-{5-(4-methoxybenzyl)-4-oxo-2-[4-(2-piperidin-1-ylethyl)phenyl]-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-3-yl}acetamide (0.13 g), trifluoroacetic acid (2.5 ml), anisole (1 ml) and trifluoromethanesulfonic acid (0.5 ml) was stirred at room temperature for 26 hours. Ice and 2N aqueous sodium hydroxide solution were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified with propylaminated silica gel column chromatography, and the obtained crystals were recrystallized from ethyl acetate to obtain the target compound (0.04 g).

Provenance & Evidence