Sodium Hydroxide → HCID 135599967, compound

HRID 1175821Notes

Reaction equation

HRID 1175821 reaction equation
[NH2:1][C:2]1[N:3]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[C:17]=2[CH3:23])[N:4]=[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7](=[O:15])[C:6]=12.[OH-:24].[Na+]>O>[NH2:1][C:2]1[N:3]([C:16]2[C:17]([CH3:23])=[C:18]([CH:19]=[CH:20][CH:21]=2)[O:22][CH2:2][CH2:6][C:7]([OH:15])=[O:24])[N:4]=[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7](=[O:15])[C:6]=12

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135599972HCID 135599972, compound

Product 1

HCID 135599967HCID 135599967, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

To a mixture of 3-amino-2-(3-hydroxy-2-methylphenyl)-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (100 mg), 1N aqueous sodium hydroxide solution (326 μl) and water (3 ml) was added dropwise γ-propiolactone (25 μl) at 80° C. The mixture was stirred at 80° C. for 2 hours, after stirring, cooled to room temperature, and the insoluble materials were filtered off. pH of the filtrate was adjusted to about 2 by adding 1N hydrochloric acid. The precipitated solid was collected by filtration, washed with water, and dried to obtain the target compound (8 mg).

Workup

  1. stirringafter stirring
  2. temperaturecooled to room temperature
  3. filtrationthe insoluble materials were filtered off
  4. additionby adding 1N hydrochloric acid
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-6c340776355044cab795c2982c7da1c5
Source dataset
uspto-grants-2010_11
Patent number
US07842701B2

Reaction notes

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