Methanesulfonamide → HCID 135600031, compound

Participants

Reaction Steps

A mixture of [3-(3-amino-4-oxo-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)-2-methylphenoxy]acetic acid (64 mg), methanesulfonamide (50 mg), 4-(dimethylamino)pyridine (25 mg), (3-dimethylaminopyropyl)ethylcarbodiimide hydrochloride (40 mg) and N,N-dimethylformamide (6 ml) was stirred at room temperature for 2 days. The reaction mixture was concentrated under reduced pressure. To the residue was added water, and then pH of the residue was adjusted to about 2 by adding a 1N hydrochloric acid. The precipitated solid was collected by filtration, washed with water, and dried to obtain the target compound (29 mg).

Provenance & Evidence