Lithium hydroxide, monohydrate → HCID 68423555, compound

Participants

Reaction Steps

A stirred solution of 1,3-dicarbomethoxybicyclo[3.1.1]heptane (1.90 g, 8.95 mmol) in tetrahydrofuran (25 mL) and isopropanol (8 mL) was treated with a solution of lithium hydroxide hydrate (2.1 g, 50 mmol) in water (25 mL), and the mixture was heated to 60°-70° C. for 3 h with stirring. The organic solvents were removed in vacuo, and the alkaline aqueous solution was cooled on an ice bath and acidified with 6N hydrochloric acid (10 mL). The solid was filtered, rinsed with cold water, and partially air dried overnight, then further dried under vacuum to afford 6.25 g (86%) of subject material as a white solid. No MS could be obtained. 1H NMR (CDCl3) δ 2.40-2.50 (m, 2H), 1.90-2.00 (m, 4H), 1.80-1.90 (m, 2H), 1.70-1.80 (m, 2H).

Provenance & Evidence