Cesium carbonate → HCID 59127148, compound

HRID 1175867Notes

Reaction equation

HRID 1175867 reaction equation
[CH3:1][C:2]([Si:5]([CH3:28])([CH3:27])[O:6][CH2:7][C@@H:8]([O:10][C:11]1[CH:12]=[C:13]([CH:23]=[C:24]([OH:26])[CH:25]=1)[C:14]([NH:16][C:17]1[CH:21]=[CH:20][N:19]([CH3:22])[N:18]=1)=[O:15])[CH3:9])([CH3:4])[CH3:3].Cl[C:30]1[CH:39]=[CH:38][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][N:31]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[CH3:1][C:2]([Si:5]([CH3:28])([CH3:27])[O:6][CH2:7][C@@H:8]([O:10][C:11]1[CH:25]=[C:24]([O:26][C:30]2[N:31]=[CH:32][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:38][CH:39]=2)[CH:23]=[C:13]([C:14]([NH:16][C:17]2[CH:21]=[CH:20][N:19]([CH3:22])[N:18]=2)=[O:15])[CH:12]=1)[CH3:9])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 536296323-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Product 1

HCID 59127148HCID 59127148, compoundYield 73.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide (1.00 g, 2.47 mmol), methyl 6-chloronicotinate (0.450 g, 2.60 mmol), and cesium carbonate (1.204 g, 3.71 mmol) in acetonitrile (15 mL) was heated at 160° C. using microwave heating for 90 minutes. The acetonitrile was removed in vacuo and the residual oil partitioned between water (50 mL) and ethyl acetate (75 mL). The ethyl acetate layer was separated, washed with brine, dried (MgSO4), and evaporated to a residue which was chromatographed on silica, eluting with 50% ethyl acetate in isohexane, to give the desired compound (0.977 g).

Workup

  1. temperatureheating for 90 minutes
  2. customThe acetonitrile was removed in vacuo
  3. customthe residual oil partitioned between water (50 mL) and ethyl acetate (75 mL)
  4. customThe ethyl acetate layer was separated
  5. washwashed with brine
  6. dry with materialdried (MgSO4)
  7. customevaporated to a residue which
  8. customwas chromatographed on silica
  9. washeluting with 50% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-6dcfd219dc2349858fd9aac5de61aad0
Source dataset
uspto-grants-2010_11
Patent number
US07842694B2

Reaction notes

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