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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176004Generated: October 27, 2026

methyl 3-(benzyloxy)-5-[(1R)-2-methoxy-1-methylethoxy]benzoate → Methyl 3-hydroxy-5-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}benzoate

https://huagongshe.com/reaction/1176004

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl 3-(benzyloxy)-5-[(1R)-2-methoxy-1-methylethoxy]benzoateHCID 59127090—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
SolventTetrahydrofuranHCID 8028—
ProductMethyl 3-hydroxy-5-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}benzoateHCID 59127121—

Reaction Steps

A solution of methyl 3-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate in THF (5 mL) and ethanol (5 mL), containing 10% palladium on carbon, was stirred under an atmosphere of hydrogen for 16 hours. The palladium on carbon was removed by filtration and the filtrate evaporated under reduced pressure to give the desired material as a clear gum (723 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842694B2
Source datasetuspto-grants-2010_11
ORD IDord-bc8ec2aff13f4116b18b66ee3babade0
Source noteuspto-grants-2010_11