反应详情

The crude material, 2-fluoro-4-nitro-benzoic acid methyl ester, from above was treated with hydrazine (1.6 mL, 51 mmol) in ethanol under reflux for 14 hrs. After removal of solvent by evaporation, the residue was washed with water. The precipitate product was filtered and dried on the vacuum pump to give the title compound which was used without further purification (4.0 g, 85% for two steps). MS (ES+): m/e=180.1 (M+H), 178.0 (M-H); LC/Method A 1.83 min.

1. temperatureunder reflux for 14 hrs
2. customAfter removal of solvent
3. customby evaporation
4. washthe residue was washed with water
5. filtrationThe precipitate product was filtered
6. customdried on the vacuum pump