HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-5-(piperidin-1-yl)benzamide → 2-Amino-5-(piperidin-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-5-(piperidin-1-yl)benzamide | HCID 2763564 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Amino-5-(piperidin-1-yl)benzamide | HCID 10727606 | 57.1% |
Reaction Steps
To 2-Nitro-5-piperidin-1-yl-benzamide (948 mg, 4.07 mmol) in Methanol (100 mL) was added Pd/C (10%) followed by H2 (1 ATM). After 10 h, the solution was filtered and concentrated. Flash chromatography (0-5% methanol in methylene chloride) afforded the title compound as a white solid (510 mg, 51% yield). FIA m/z 220.1 (M+H) 218 (M-H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842712B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-69081cadd3e44c5a855e23a4e4285062 |
| Source note | uspto-grants-2010_11 |