反应详情

6-[6-(5-Cyclopropyl-2H-pyrazol-3-ylamino)-5-nitro-pyridin-2-ylamino]-1,2-dihydro-indazol-3-one was prepared by the reaction of (6-Chloro-3-nitro-pyridin-2-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine and 6-Amino-3-oxo-2,3-dihydro-indazole-1-carboxylic acid tert-butyl ester in a similar manner as described above to afford 17 mg of the desired product as a bright yellow solid (16.2% yield). H-NMR (CD3OD) δ 8.32 (d, 1H), 7.68 (d, 1H), 7.65 (s, 1H), 7.17 (d, 1H), 6.38 (d, 1H), 6.24 (s, 1H), 1.79 (m, 1H), 0.84 (m, 2H), 0.48 (m, 2H). MS (ES+): m/e=393.2 (M+H), 391.2 (M-H); LC/Method A/4.149 min, 100% purity by area %.