HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzoic Acid → 1-(4-Aminobenzoyl)-3-dimethylamino-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzoic Acid | HCID 978 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Aminobenzoyl)-3-dimethylamino-pyrrolidine | HCID 22567471 | 47.1% |
Reaction Steps
A mixture of 4-aminobenzoic acid (1.4 g, 10 mmol), 3-(dimethylamino)-pyrrolidine (1.5 g, 13 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (2.5 g, 13 mmol) in CH2Cl2 is stirred at room temperature for 16 h, diluted with CH2Cl2, washed with water, dried over MgSO4 and concentrated in vacuo to give the title compound (1.1 g), identified by NMR analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842715B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-2718d3fc111643df804e2b37dedaa82f |
| Source note | uspto-grants-2010_11 |