Benzo(b)thiophene, 3-bromo- → 1-[4-(1-Benzothien-3-ylamino)benzoyl]-N,N-dimethylpyrrolidin-3-amine

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Reaction Conditions

Reaction Steps

A mixture of 1-(4-aminobenzoyl)-3-dimethylamino-pyrrolidine (50 mg, 0.21 mmol), 3-bromobenzothiophene (50 mg, 0.23 mmol), sodium tert-butoxide (44 mg, 34 mmol), tris(dibenzylideneacetone)dipalladium(0) (3 mg, 0.002 mmol), CTC-Q-Phos (6 mg, 0.004 mmol) is heated to 80° C. for 16 h and concentrated in vacuo. The resultant residue is dissolved in a mixture of DMSO, methanol and water and purified by reverse-phase semi-preparative HPLC1 to give the title compound as a white powder (11 mg), identified by HPLC and mass spectral analyses. Retention Time, 2.62 min.; MS [366.2 m/e (M+H)]. 1Semi-preparative HPLC Conditions: A=0.02% TFA in water, B=0.02% TFA in acetonitrile, 10-95% B in 8 min., 34 mL/min, 50° C., 215 nm detection, Waters Xterra™ 20×50 mm column.

Provenance & Evidence