Diisopropylethylamine → HCID 17757345, compound

Participants

Reaction Steps

A mixture of 1-(4-aminobenzoyl)-3-dimethylamino-pyrrolidine (46 mg, 0.2 mmol), quinoline-2-carbonyl chloride (38 mg, 0.2 mg) and diisopropyl ethyl amine (0.1 mL, 0.6 mmol) in CH2Cl2 is stirred at room temperature for 5 h and concentrated in vacuo. The resultant residue is dissolved in a mixture of DMSO, methanol and water and purified by reverse-phase semi-preparative HPLC, using the same HPLC conditions described in Example 1, to give the title compound as a white powder (10mg), identified by HPLC and mass spectral analyses. Retention Time, MS [366.2 m/e (M+H)].

Provenance & Evidence